4-Thiazolecarboxylic acid, 2-bromo-

4-Thiazolecarboxylic acid, 2-bromo- - Names and Identifiers

Name	2-Bromo-4-thiazolecarboxylic acid
Synonyms	2-Bromo-4-carboxy-1,3-thiazole 2-Bromo-4-thiazolecarboxylic acid 2-BROMOTHIAZOLE-4-CARBOXYLIC ACID 2-BROMO-4-THIAZOLECARBOXYLIC ACID 2-bromo-1,3-thiazole-4-carboxylate 2-Bromo-thiazole-4-carboxylic acid 4-Thiazolecarboxylic acid, 2-bromo- 2-Bromo-1,3-thiazole-4-carboxylic acid 2-BROMO-1,3-THIAZOLE-4-CARBOXYLIC ACID
CAS	5198-88-9
InChI	InChI=1/C4H2BrNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)/p-1
InChIKey	BEGREHRAUWCAHV-UHFFFAOYSA-N

4-Thiazolecarboxylic acid, 2-bromo- - Physico-chemical Properties

Molecular Formula	C4H2BrNO2S
Molar Mass	208.03
Density	2.062±0.06 g/cm3(Predicted)
Melting Point	212-214
Boling Point	350.0±15.0 °C(Predicted)
Flash Point	165.5°C
Vapor Presure	1.69E-05mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
Maximum wavelength(λmax)	['243nm(MeOH)(lit.)']
pKa	3.13±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
MDL	MFCD04115729

4-Thiazolecarboxylic acid, 2-bromo- - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
HS Code	29341000
Hazard Note	Irritant

4-Thiazolecarboxylic acid, 2-bromo- - Reference Information

uses

thiazole compounds are important pharmaceutical and chemical intermediates. thiazole compounds have low toxicity, excellent biological activities (such as acaricidal activity, bactericidal activity, inhibition of insect pheromone synthesis, etc.) and various characteristics of institutional changes. Thiazole 2-bromo-4-thiazole carboxylic acid is a key intermediate in the synthesis of thiabendazole.

Preparation

Using thiourea as raw material and ethyl bromopyruvate as reagent, 2-aminothiazol-4-ethyl formate was synthesized without solvent, and then 2-bromothiazol-4-ethyl formate was obtained by DM SO and sodium nitrite high temperature diazotization method, finally, the target 2-bromo-4-thiazole carboxylic acid is obtained by saponification with potassium carbonate-methanol solution

Last Update：2024-04-09 02:00:09